Time analysis showed a significant decrease over time in TB-IRIS patients and HIV+TB+ controls for the MFI of PD-1 and IL-27R, and the percentage of PD-1+KLRG1+ cells within the CD3-CD8lo lymphocytes (Friedman test p ≤ 0.030, with Dunn’s post-hoc test p ≤ 0.037). Here, IL27RA is linked to tuberculosis.