Since CD4+ T cell exhaustion is a hallmark of long-term HIV infection, we assessed if the expression patterns of PD-1, KLRG1 and IL-27R on CD45RO+CD4+ T cells before and during ART differed in HIV-TB patients who did and did not develop TB-IRIS (Fig 1 and S3 Fig). The gene discussed is CD4; the disease is HIV infectious disease.