Time analysis showed a significant decrease over time in TB-IRIS patients in the MFI of TLR2 and TLR4 (Friedman test p = 0.018 & Dunn’s post-hoc test p = 0.018 for both markers) and in the MFI of TRAILR for TB-IRIS patients and HIV+TB+ controls (Friedman test p = 0.030 & Dunn’s post-hoc test p = 0.037 for each group). The gene discussed is TLR2; the disease is tuberculosis.