Individuals with anemia (<13 g/dL in men or <11 g/dL in women), no albuminuria, and a GFR ≥60 mL/min/1.73 m2, who are considered a low-risk group by the KDIGO guidelines, had a comparable risk to those with a GFR 30–59 mL/min/1.73 m2, no albuminuria, and normal Hb (the moderate to high-risk group). The gene discussed is GSTM1; the disease is anemia (phenotype).