On the other hand, homozygous Caucasian carriers of the SNP rs12609744 G allele, the rs11085823 G allele, and the rs7249143 A allele in the 5’-upstream region of DNASE2, leading to low in vivo levels of enzyme activity through reduction of promoter activity in the gene, are considered to have an increased risk of rheumatoid arthritis [24,25]. This evidence concerns the gene DNASE2 and rheumatoid arthritis.