Notably, BRCA1-deficient breast cancers with PTEN mutation, but not BRCA1-deficient breast cancers without PTEN mutation, had significantly higher T cell-inflamed signature scores compared to BRCA-proficient breast cancers (P = 9.3 x 10−3 and 0.07, respectively; Fig 4G). The gene discussed is BRCA1; the disease is breast carcinoma.