DRB1-30 was a primary determinant of anti-nRNP risk, DRB1-70 of anti-Ro/La risk, and DPB1-11 of anti-Sm risk; none of these residues were GWS for overall SLE risk (conversely, DRB1-11/13 was shared between overall SLE risk and nRNP+, Ro/La+, and ACL+ status). This evidence concerns the gene ACLY and systemic lupus erythematosus.