These last, along with other observations (e. g. HLA-DRB1-09:01 and DRB1-13Phe, risk for SLE and nRNP+, but protective for Ro/La+; HLA-DRB1*16:02, strongly risk for SLE but no detectible risk for tested autoantibodies), suggest that SLE and specific autoantibody development share some genetic risk elements but diverge at others. The gene discussed is CALR; the disease is systemic lupus erythematosus.