MHC is implicated in the pathogenesis of every described autoimmune disease, including celiac disease[9], type I diabetes (T1D)[10], rheumatoid arthritis (RA)[11], Sjögren’s syndrome[12], psoriatic arthritis[13], multiple sclerosis (MS)[14], and SLE[8, 15–17]. Here, HLA-C is linked to systemic lupus erythematosus.