Indeed, upon residue-mapping of MHC risk for RA, the signal primarily localized to DRB1-11-Val/Leu, DRB1-71-Lys/Arg, DRB1-74Ala, B-9Asp and DPB1-9Phe[29], with 6/7 experimentally determined RA-risk residues coming from the predicted list (S10b Table). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.