Specific MHC risk alleles and residues have similarities and differences with other autoimmune diseases, e. g. DRB1*15:01 and DQB1*06:02 are shared between SLE and multiple sclerosis (MS)[14]; whereas DQB1*03:02 confers risk for T1D[14] but protection for SLE. The gene discussed is HLA-DRB1; the disease is multiple sclerosis.