Positive charge at specific residues can be risk for autoimmune (Hashimoto’s) thyroiditis[38] (DRB1-26Tyr, 30Tyr, 70Gln, 71Lys, 74Arg), T1D (DRB1-13His, 67Leu, 71Arg)[39], vitiligo (DRB1-30Leu, 37Phe, 70Asp, 71Arg), and Graves’ disease[40] (DPB1-35Leu, 9Phe; A-9Phe/Tyr; B-45Lys, 67Phe/Tyr; DRB1-74Leu). The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.