Specific MHC risk alleles and residues have similarities and differences with other autoimmune diseases, e. g. DRB1*15:01 and DQB1*06:02 are shared between SLE and multiple sclerosis (MS)[14]; whereas DQB1*03:02 confers risk for T1D[14] but protection for SLE. This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.