Emerging evidence suggested that EMT functions importantly in cancer initiation, progression and metastasis.16 In this study, qRT‐PCR analysis revealed that AKIP1 silencing led to the up‐regulated expression of E‐cadherin and the down‐regulated expressions of N‐cadherin and Slug, but did not markedly influence other transcription factors (Snail, ZEB1, SIP1 and Twist). The gene discussed is TWIST1; the disease is cancer.