Interestingly, transcription factor (such as Snail, Slug, ZEB1, SIP1 and Twist), as a key regulators of EMT, was found to be an intracellular element related to cellular proliferation, invasion and metastasis.21 Herein, we discovered the role of Slug in AKIP1‐mediated regulation of GC proliferation and metastasis. The gene discussed is ZEB1; the disease is gastric cancer.