Inflammatory state manifested by high CRP levels may lead to low 25(OH)D levels, and reduction of vitamin D contributes to the dysregulation of immune and inflammatory responses, such as respiratory infections and psoriasis.3, 35, 36 Moreover, studies in animal models and cell culture showed that vitamin D treatment could arrest nuclear factor κB translocation and suppress its activity,37 and could produce anti‐inflammatory effects by modulating immune cells and signaling pathways.3 The gene discussed is CRP; the disease is respiratory tract infectious disorder.