Alterations in nuclear morphology have been correlated with both aging and cancer, and molecular and genetic studies have shown that mutations in lamins, nucleoporins, LEM and SUN domain-containing proteins and other NE components are related to a wide spectrum of diseases (reviewed in Burke and Stewart 2014; Dahl et al. 2006; Janin et al. 2017; Woulfe 2008). Here, CIMAP2 is linked to cancer.