Specifically, administration of two PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to four MM cells (L363, OPM-1, OPM-2 and U266) resulted in induction of apoptosis through increased caspase-3 activation, and mitochondrial membrane perturbation with no effect on normal human peripheral mononuclear cells[104]. This evidence concerns the gene CASP3 and Miyoshi myopathy.