CD274 and neoplasm: TAMs display an M2-like phenotype and secrete IL-10, prostaglandin E2 (PGE2), and chemokines to attract and induce Tregs.18, 41 Moreover, TAMs express iNOS and Arg1, and they upregulate PD-L1 on their cell surface, which inhibits CD8+ T cell function.18, 42 These mechanisms hamper DC therapy-induced anti-tumor immunity.