A phase II, open-label, single-arm clinical trial combined ipilimumab treatment with DCs electroporated with Trimix-mRNA (CD40L, CD70, constitutive active TLR4) and mRNA encoding for MAGE-A3, MAGE-C2, tyrosinase3, or gp100 in patients with stage III and IV melanoma.111. Here, PMEL is linked to melanoma.