CD40 and pancreatic neoplasm: Immunoinhibitory TAMs are abundant in many solid tumors.151, 152 These TAMs can be either depleted via colony-stimulating factor 1 receptor (CSF-1R) blockade or skewed into an immunostimulatory M1 phenotype by CD40 agonistic mAb.153, 154, 155, 156, 157, 158, 159 CSF-1R blockade increased the efficacy of chemotherapy in pancreatic tumor-bearing mice.160