It is notable that the serum levels of IL-8 were obviously decreased in four patients positive with anti-EJ in the present study, but to a lesser extent. Gono T showed that IL-8 levels were significantly higher in the ILD subset of myositis especially in anti-MDA5-ILD, indicating that serum IL-8 is a useful predictor for fatal outcome due to ILD [28]. This evidence concerns the gene IFIH1 and interstitial lung disease.