In their in vivo research, Cao et al. used mice with double knockout (dKO) in the Ccl2 (C-C motif chemokine ligand 2) and Cx3cr1 (C-X3-C motif chemokine receptor 1) genes, which had acquired retinal injuries similar to those observed in AMD. The gene discussed is CX3CR1; the disease is age-related macular degeneration.