Our study first provided that the combination of SNX-2112 with TRAIL could enhance cancer cell death by downregulating antiapoptosis proteins, including Bcl-2, Bcl-XL, and FLIP, and elucidate the mechanism by which SNX-2112 sensitizes TRAIL to apoptosis in cervical cancer cells. The gene discussed is TNFSF10; the disease is cervical carcinoma.