Meanwhile, pre-miR-122 or si-SBP1 treatment alleviated the development of TNBS-induced CD; reduced the levels of 8-OHdG, MDA, IL-6, IL-8, and ICAM; and enhanced the expressions of GSH, GPX1, and SOD, which indicated an antioxidative stress effect and protection of intestinal mucosa in CD. Here, GPX1 is linked to Cowden disease.