Meanwhile, pre-miR-122 or si-SBP1 treatment alleviated the development of TNBS-induced CD; reduced the levels of 8-OHdG, MDA, IL-6, IL-8, and ICAM; and enhanced the expressions of GSH, GPX1, and SOD, which indicated an antioxidative stress effect and protection of intestinal mucosa in CD. This evidence concerns the gene SOD1 and Cowden disease.