NFE2L2 and epilepsy: Some authors have reported the neuroprotective role that the NRf2 factor could play in epilepsy; when an increase in cellular oxidative stress is generated due to cellular overexcitation, the protection mechanisms are increased by the induction of cytoprotective enzymes mediated by this factor, in astrocytes and neurons in culture increased levels of Nrf2 as well as some antioxidant enzymes that have been observed [13, 14].