EGFR and head and neck squamous cell carcinoma: Moreover, the authors also demonstrated that an increased EGFR gene copy number in OPLs is a precursor to EGFR gene amplification in HNSCC (as is chromosome 7 increased copy number) and an important oncogenesis-driving effector in oral oncogenesis reducing the possibility of having healing at the surgical site and final good prognosis for the patient.