This investigation referred only oral cancers that developed in the same site as the OPL; 25% of the patients positive for podoplanin developed cancer, compared with 4% of the patients negative for podoplanin; 24% of the patients positive for deltaNp63 developed cancer, compared with 7% of the patients negative for deltaNp63; and 40% of the patients positive for all the biomarkers developed oral cancer, compared with 9% of the patients with no, one, or two positive biomarkers. Here, PDPN is linked to cancer.