Therefore, it is associated with OSCC development in patients with oral premalignant lesions (OPLs) expressing high EGFR, particularly OSCC developing at the site of a high-expression OPL; the authors also suggested that EGFR inhibitors might prevent oral cancer in patients with OPLs having an increased EGFR gene copy number. Here, EGFR is linked to dysplastic oral keratinocyte.