In our previous study, we found that SHH, PTCH-1, and GLI-2 were overexpression in the paracarcinoma tissue of HBV-related HCC patients, and they have positive correlation with HBx (data not show), which revealed that maybe HBx activate the SHH pathway, contributing to HBV-related HCC development. Here, SHH is linked to hepatocellular carcinoma.