SHH and liver disorder: Several lines of evidence confirm that abnormality of the SHH pathway plays an important role in the liver diseases. Chen et al. validated that deregulating the GLI-1 could inhibit the migration and invasion in hepatocellular carcinoma. Kim et al. have found that hepatic stellate cells could stimulate the proliferation and migration of cholangiocarcinoma cells through HH signaling activation [27].