QKI and schizophrenia: Interestingly, GOMAFU can directly interact with the splicing factors quaking (QKI) and SRSF1 (serine/arginine-rich splicing factor 1), and when GOMAFU is dysregulated, the alternative splicing resembles that seen in schizophrenia-associated genes DISC1 and ERBB4 (Figure 1D).