MeCP2 associates with HDAC3 as part of the NCoR/SMRT co-suppressor complex (Lyst et al., 2013), and MeCP2 missense mutations that occur in Rett Syndrome prevent this interaction (Nan et al., 1998; Ebert et al., 2013; Lyst et al., 2013). The gene discussed is MECP2; the disease is Rett syndrome.