PTX3 by interacting with fibrin matrix (15), FGF2 (109), and complement components (14) regulates the main common processes in tissue repair (139–141) and in tumor-promoting angiogenesis and inflammation (Table 1) (61, 142, 143), thus suggesting that the roles of PTX3 in tissue repair and cancer are functionally associated. Here, FGF2 is linked to cancer.