However, other studies propose that in specific models PTX3 has a pro-tumorigenic function, by promoting tumor cell migration and invasion and macrophage infiltration, suggesting that PTX3 may have different functions on carcinogenesis depending on the tissue and cancer type, and possibly cell- and stimulus-dependent PTX3 glycosylation (and sialylation) profiles, which needs further dissection. The gene discussed is PTX3; the disease is cancer.