PTX3 derived from macrophages and mesenchymal cells forms a tripartite PTX3/fibrin/plasminogen complex at acidic pH that promotes pericellular fibrinolysis (15) In a mouse model of arterial thrombosis, PTX3 inhibits platelet adhesion and aggregation by targeting fibrinogen and collagen (62). This evidence concerns the gene PTX3 and Arterial thrombosis.