PTX3 by interacting with fibrin matrix (15), FGF2 (109), and complement components (14) regulates the main common processes in tissue repair (139–141) and in tumor-promoting angiogenesis and inflammation (Table 1) (61, 142, 143), thus suggesting that the roles of PTX3 in tissue repair and cancer are functionally associated. This evidence concerns the gene FGF2 and neoplasm.