In psoriasis, the absence of Th2-defining cytokines [interleukin (IL)-4, IL-5, and IL-10] (18) and the increased presence of Th1 cytokines (interferon gamma (IFN-γ), tumor necrosis factor (TNF) and IL-12) prompted researchers to classify psoriasis as a Th1-mediated disease (18). This evidence concerns the gene IL10 and psoriasis.