INS and obesity due to melanocortin 4 receptor deficiency: In a recent study, we investigated the impact of a periodized 14 days low protein/high carbohydrate (pLPHC) diet/14 days HFD cycles provided for 3 months in conjunction with voluntary running wheel exercise training (termed exercise training from hereon) on obesity-development, whole-body metabolism, insulin sensitivity, and cell signaling in liver and skeletal muscle (Li et al., 2018a).