So far, the majority of the data available on Drp1 concerns the effects of the inhibition of mitochondrial fission by Drp1 silencing; considering the association between neurological disorders and high Drp1 levels we focused our study on the effects of increased levels of Drp1 on neuronal differentiation of P19 cells, a suitable model for the study of mammalian neuronal cell pathophysiology (Bain et al., 1994; Vantaggiato et al., 2009, 2011). This evidence concerns the gene DNM1L and nervous system disorder.