Tumor treatments tended to influence overall Il1α gene expression (Fig. 7A;p = 0.06), which was driven by samples from the dark phase, in which tumor-bearing mice displayed greater Il1α brain gene expression relative to surgical controls (tumor main effect: F2,7 = 5.1, p < 0.05; post hoc Bonferroni: p < 0.05). Here, IL1A is linked to neoplasm.