Moreover, reduced total investigation in all mice exposed to a tumor (combined tumor-bearing and -resected groups) was predicted by elevated brain Ilr1, Icam1 and Itgam gene expression (Supplementary Fig. 4A–C; p < 0.05 in both cases), while reduced familiar object investigation, specifically, was predicted by elevated brain Ilr1, Icam1 and Mapk1 gene expression (Supplementary Fig. 4D–F;p < 0.05 in both cases). The gene discussed is MAPK1; the disease is neoplasm.