Circulating levels of IL-1β and CXCL1 were higher in the light phase for tumor-free control mice (Fig. 4A-B; IL-1β: t8 = 2.3, p < 0.05; CXCL1: t8 = 10.9, p < 0.0001), but these time-of-day differences were lost in both the tumor-bearing and -resected mice. The gene discussed is CXCL1; the disease is neoplasm.