Tumors (Fig. 6B; Cd4, tendency in Myd88, p = 0.07) and tumor resection (Fig. 6A–D; Myd88, Cd4, Tlr9, Cd38) eliminated these time-of-day differences by reducing light-phase gene expression relative to controls and or increasing dark phase expression. The gene discussed is TLR9; the disease is neoplasm.