Ultimately, the uPICs exert significant antitumour activity for a spontaneous pancreatic tumour model and an orthotopic brain tumour model by transporting an apoptosis-inducing siRNA coding polo-like kinase 1 (PLK1) and an ASO coding turine upregulated gene 1 (TUG1), respectively. This evidence concerns the gene PLK1 and pancreatic neoplasm.