Moreover, the comparable significant antitumour activity of siRNA/uPIC was also elicited by delivering a therapeutic siRNA encoding vascular endothelial growth factor (siVEGF) (Supplementary Fig. 12a), which can suppress tumour growth by disturbing angiogenesis in tumour tissues27,28 without any change in body weight (Supplementary Fig. 12b). Here, VEGFA is linked to neoplasm.