ATR and colonic neoplasm: Our data show the importance of BUB1 to maintain the stability of aneuploidy cancer cells, and are in line with papers that show (i) the key role of BUB1 in maintaining human cell viability in the near haploid cell line HAP-1, which is derived from the chronic myeloid leukemia KBM-7 cell line [32]; (ii) the robust spindle check point of aneuploid colon cancer cell lines [33]; and (iii) the capacity to sensitize tumor cells to taxanes, ATR and PARP inhibitors by hindering BUB1 activity in triple-negative breast cancer in vitro and in vivo models [34].