HIF1A and neoplasm: Initially, the PDX model from PT5 was used to detect the potential drug targets, and test the tumor growth inhibitory effects of PX-478 (S-2-amino-3-(4′-N,N,-bis(chloroethyl)amino) phenyl propionic acid N-oxide dihydrochloride), a small molecule that selectively inhibits hypoxia-induced HIF1A mRNA expression and translation [19,20,21], and neratinib on this HR-/HER2+ subtype.