NLRP3 and chronic kidney disease: In particular, the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome, an extensively characterized inflammasome family member, is widely implicated in a variety of renal injuries, including acute and chronic kidney disease (CKD) [19,20,21]; oxalate and uric acid crystal nephropathy [22,23]; and diabetic nephropathies [24].