Mechanistically, loss of α3β1 in PCa results in the inhibition of the Abelson-related gene (Arg/abl2) tyrosine kinase cascade, which dephosphorylates the p190Rho-Guanosine triphosphate (GTP)ase activating protein-(GAP)/p120RAS-GAP (p190RhoGAP/p120RAS-GAP complex [127]. This evidence concerns the gene ABL2 and posterior cortical atrophy.