In addition, we analyzed the expression profiles of ELKs in cancer tissues in the UniGene database and observed that ELK1 is a major expression type in gastrointestinal tumor, lymphoma, pancreatic tumor, primitive neuroectodermal tumor, retinoblastoma, and soft tissue/muscle tissue tumor (Supplementary Figure S4b). The gene discussed is ELK1; the disease is retinoblastoma.