Thus, activation of Ras-Rafs-MEKs-ERKs in human cancers results in the activation of downstream kinases of ERKs such as p90 ribosomal S6 kinases (p90RSKs; RSKs) including RSK2, indicating that RSKs are key effector kinases enhancing cell proliferation and transformation [49,50]. The gene discussed is RPS6KA3; the disease is cancer.