Bradley et al. [97] demonstrated the role of genetic variants in CRHR1 as moderators of the effects of child abuse on adult depressive symptoms in two independent populations which was further confirmed by a replication study which reported the association of TAT (rs7209436, rs110402, and rs242924) haplotype in CRHR1 in predicting the adult depression [98,99]. Here, CRHR1 is linked to major depressive disorder.