INS and major depressive disorder: Furthermore, 56 KEGG pathways (24 from Set A and 32 from Set B) were identified with 9 commonly enriched pathways, namely Cushing syndrome, Retrograde endocannabinoid signaling, Axon guidance, cAMP signaling pathway, Glutamatergic synapse, Insulin secretion, Gap junction, Gastric acid secretion, and Salivary secretion, from Set A and Set B. In the view of MDD etiology, the most interesting molecular pathways are Axon guidance, Glutamatergic synapse, and Cushing syndrome.