For example, it inhibited the function of phosphorylated AKT, CyclinD1, CDK4, Bid, Mcl-1 and Bcl-xL, and promoted the expression of p-BRCA1, p-ATM, p53, p21, p38, Bax and Bid, while triggering apoptosis and S phase arrest in a study of bladder cancer cells [33]. This evidence concerns the gene BID and urinary bladder carcinoma.