In AML, two mutations of the FLT3 gene are recurrently found: (i) FLT3 internal tandem duplications (FLT3-ITDs) of the juxtamembrane domain occurring in around 25% of patients) [21] and (ii) point mutations in the tyrosine kinase activating loop of the kinase domain FLT3-TKD (typically at codon D835) in about 5–10% of patients [21]. The gene discussed is FLT3; the disease is acute myeloid leukemia.