The authors suggested that salvage treatment, primarily allogeneic stem cell transplantation (HSCT), may not have been equally potent in patients relapsing after placebo or sorafenib therapy, since sorafenib may select for resistant AML subclones In a lower intensity treatment approach azacitidine plus sorafenib demonstrated valid clinical activity in r/r FLT3-ITD positive AML [overall response rate (ORR) 46%, 16% CR] and elderly de novo FLT3-ITD positive AML patients (ORR 78%, 26% CR) [28,29]. This evidence concerns the gene FLT3 and acute myeloid leukemia.