APC and cancer: Consistent with previous data suggesting that centrosome amplification on its own is not an independent driver of cancer development [70,71], induction of Pik3caH1047R alone in this model did not produce neoplastic lesions or cancer, as assessed in multiple organs but accelerated the onset of cancer when combined with intestine-specific heterozygous deletion of the Apc tumour suppressor gene (Apcflox/+ mice) [66].