The failure of Pik3caH1047R alone to induce tumours in this model (and also in the knock in models of Robinson [63] and Berenjeno [66]) is different from the transgenic mouse models driven by exogenous promoters, where Pik3ca mutation alone was able to induce lung, breast and colon tumours [34,39,40,41,44]. The gene discussed is PIK3CA; the disease is neoplasm.