TP53 and breast cancer: Expression of the MYR-p110α in the mammary gland, induced by instillation of an adenovirus expressing Cre-recombinase into mammary ducts, by itself had minimal transforming activity but in an oncogenic mouse model with a homozygous p53 deletion and a KrasG12D missense mutation, the addition of MYR-p110α accelerated mammary tumour initiation but not tumour growth rate [38].