PPBP and infection: Interestingly, we observed a persistent trend in the down-regulation of PPBP, which is a potent neutrophils chemoattractant and activator involved in platelet activation, but also a protein involved in the host defense against bacterial and fungal infections [26]; it is possible that there is a negative role in the progression of EBOV infection, to our knowledge never reported so far, which is corroborated also by the fact that we found its expression inversely correlated with viremia levels in fatal cases during the late phase of infection.