Pathogenic alterations in SCN1A (associated with Dravet syndrome, a genetic epileptic encephalopathy in which a SCN1A loss-of-function mutation is found in 80% of cases) or in SCN8A (associated with early-infantile encephalopathy) are examples of variants co-expressed in both brain and heart that increase the risk of SUDEP [38]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.