The MRM analysis of adducts obtained upon HSA pronase E digestion to aminoacids was used by Sabbioni et al. [55] for the identification of Lys adducts of 4,4′-methylenediphenyl diisocyanate (MDI) in workers with and without diisocyanate occupational asthma, which enabled the identification of substantially higher levels of adducts in asthma case suggesting that HSA MDI-Lys adducts are suitable for industrial biomonitoring. This evidence concerns the gene ALB and occupational asthma.