Despite that PAD4 is the only one displaying a nuclear localization signal (NLS), PAD2 has recently been detected in the nuclei of mammary epithelial cells (Cherrington et al., 2010) and has been found to inhibit transcription through RNA polymerase (Pol) II citrullination in breast cancer cell line T47D (Sharma et al., 2019). This evidence concerns the gene PADI2 and breast cancer.