GSDMD and infection: The activation of caspase-1 in macrophages leads to the proteolytic maturation of pro-interleukin (IL)-1β and pro-IL-18 and pyroptosis through the proteolysis of gasdermin-D (GSDMD) (Broz and Dixit, 2016), which together promote immunity against infection (Liu et al., 2012, Nordlander et al., 2014, Song-Zhao et al., 2014).