We applied our approach to three dominant traits with known pathogenic variants, breast cancer in family S (Ataei‐Kachouei et al., 2015; BRCA2 gene), neuroblastoma in family M (McConville, Reid, Baskcomb, Douglas, & Rahman, 2006; Mosse et al., 2004; PHOX2B gene), and low‐frequency nonsyndromic hearing impairment in family L (Bespalova et al., 2001; WFS1 gene). The gene discussed is WFS1; the disease is breast cancer.