38, 39, 40, 41 High expression of ANXA2 has been shown to have an unfavorable prognosis in multiple malignancies.42 Within this group of potential biomarkers, it is of interest to note that the level of expression in EVs from normal versus PCa cell lines is not always in the same direction as the NAP versus PCa tissue MS (Table 1). Here, ANXA2 is linked to posterior cortical atrophy.