XPO1 (also known as CRM1) mediates nuclear export of proteins and RNAs and its differential expression has been linked to multiple types of cancer.20, 21, 22 These transported proteins play a role in tumor signaling pathways, including the AR‐pathway.23, 24 XPO1 has already been identified as a marker for several malignancies.21 We identified this protein to be higher expressed in EVs derived from the VCaP PCa cell line.7 In this current study, we observed higher expression in PCa tissue as compared to NAP, which could explain the increased EV expression. Here, AR is linked to posterior cortical atrophy.