Interactions between cancer cells and the surrounding inflammatory microenvironment as well as the secreted cytokines and growth factors, such as IL8 and CCL2, play key roles in the development of Doc resistance.22, 23, 24, 25 Moreover, anti‐inflammatory agent resulted in more enhanced sensitivity of PCa cells to Doc‐induced apoptosis and improve the efficacy of Doc.26, 27 In the tumor inflammatory microenvironment, CD4+ T cells are important components and play an important role in PCa progression. This evidence concerns the gene CD4 and posterior cortical atrophy.