Gastrointestinal MNV infections revealed that Stat1-/-Nlrp3-/- mice survived statistically significantly longer than their Stat1-/-Nlrp3+/- littermates (Fig 5E), clearly showing that abrogating Nlrp3-mediated IL-1β maturation has a beneficial effect in overall MNV-induced immunopathology in STAT1-deficient mice. The gene discussed is NLRP3; the disease is infection.