STAT1 and gastroenteritis: As an in vivo model for norovirus-induced gastroenteritis with concomitant systemic inflammatory responses, we infected Stat1-/- mice via oral gavage with the non-persistent MNV-1 CW1 strain [16] (hereafter referred to as MNV), which was lethal for infected Stat1-/- mice but not for their Stat1+/- littermates (S1A Fig).