Although the role of FGF21 and KLB in AD are not currently known, the association of FGF21 with the Cadetblue2 mega-module, containing nominally associated genes from AD GWAS studies, is a possible additional validation of the utility of our studies integrating protein-protein interaction information (tissue non-specific), AD GWAS (tissue non-specific) and brain ethanol-responsive gene expression. This evidence concerns the gene FGF21 and Alzheimer disease.