TNFRSF1A and type 2 diabetes mellitus: Given the elevated IL‐6, TNF‐R1, and sST2 levels in stage B HF patients with both T2DM and depressed mood, additional attention and interventions to forestall potential transition to symptomatic stage C HF may be warranted.36 The pathophysiology of stage B HF, combined with the presence of T2DM, might synergize to advance the likelihood of poorer outcomes.