PVT1 and non-small cell lung carcinoma: For example, Nie and colleagues reported that lncRNA ANRIL promotes cell proliferation in NSCLC by binding to EZH2 and recruiting it to KLF2 and P21 promoter regions to repress their transcription.29 In addition, Wan et al found that lncRNA PVT1 promotes NSCLC cells growth by epigenetically repressing LATS2 expression through interacting with EZH2.30 Interestingly, our findings also showed that knockdown of LINC00511 or EZH2 could increase P21 expression in ovarian cancer cells.