ACTH‐secreting pituitary adenomas, originating from pituitary corticotroph cells, are related to substantial morbidity and cause adrenal hypercortisolaemia, which is often referred to as Cushing's disease.47 The pathogenesis of Cushing's disease is obscure and it remains difficult to treat successfully.48, 49, 50 The present study aimed to elucidate the mechanistic role of TSP‐1 in regulating the tumour function of pituitary adenomas. This evidence concerns the gene POMC and neoplasm.