The genes regulated by CD147 phosphorylation were detected by RNA sequencing.<h4>Results</h4>We identified phosphorylated serine-246 in the C terminus of CD147 in primary HCC tissues, whereas serine to alanine substitution mutation analysis suggested that CD147 is phosphorylated mainly at serine-252 in HCC-derived Huh-7 cells. Here, BSG is linked to hepatocellular carcinoma.