IFNG and infection: During the early period of viral injection, the expression of SERPINA1 was no significant difference in the liver, while it was rapidly increased in the kidney tissue, which may be related that during suffering the infection of the viral antigen, the host's various non-specific defenses, such as natural killer lymphocyte cell immunity, secrets more IFN-α and IFN-γ [31] to regulate the expression of SERPINA1 gene regulation pathway, which lead to an increase in early SERPINA1 gene expression.