Given, HNRNPD, one of the best‐characterized ARE‐binding proteins (AUBPs), directly binds to many ARE‐mRNAs and assembles other factors necessary in recruitment of the mRNA degradation machinery, reduced HNRNPD protein leads to less interaction with ARHGDIB mRNA, subsequently increasing ARHGDIB mRNA stability and protein expression, as well as promoting BC cell invasion. Here, ARHGDIB is linked to breast cancer.