Further, we transfected shRNAs specifically targeting human HNRNPD into UMUC3(shATG7#1) cells, as shown in Figure 6G. The inhibition of HNRNPD expression in UMUC3(shATG7#1) restored ARHGDIB mRNA stability and its protein expression, as well as BC cell invasion (Figure 6H–J), suggesting that HNRNPD might be a mediator linking ATG7 to ARHGDIB and associated with BC invasion. This evidence concerns the gene HNRNPD and breast cancer.