BECN1 and breast cancer: Consistently, the deficiency of autophagy in ATG7 knockdown transfectants also showed inhibition of the invasive abilities in both T24 and UMUC3 cells (Figure 3G–J), while the deficiency of BECN1 promoted the invasive abilities in UMUC3 cells (Figure S1B–D, Supporting Information), suggesting that ATG7 plays a critical role in human invasive BC invasion.