ARHGDIA, ARHGDIB, RAC1,2,3, and ras homolog gene family, member A (RHOA) are key regulators of actin polymerization, cell migration, and cancer invasion.18 To clarify the mechanism underlying the ATG7 regulation of BC invasion, ARHGDIA, ARHGDIB, RAC1,2,3, and RHOA proteins were determined. The gene discussed is RHOD; the disease is breast cancer.