ATG7 and hepatocellular carcinoma: For example, depletion of ARHGDIB expression inhibits the ability of invasion and migration of pancreatic carcinoma.10 ARHGDIB is also reported to promote cell invasion and proliferation by activating Akt in hepatocellular carcinoma.41 Here, we show that knockdown of ATG7 almost completely abolished ARHGDIB expression in both T24 and UMUC3 cells, as well as in their xenograft tumors.