Consistent with the ATG7 negative regulation of HNRNPD in vitro cultured UMUC3 cells, HNRNPD protein expression was markedly increased in xenograft tumor tissues attained from nude mice injected with UMUC3(shATG7) cells (Figure 6E,F), and the similar change of NCL protein expression (Figure S3D,E, Supporting Information). This evidence concerns the gene ATG7 and neoplasm.