In addition to nerve signal transduction, CaMKII also plays an essential role in regulating tumor cell survival, proliferation, and differentiation.14, 15, 16, 17 Nevertheless, the biological effects of nano‐C60 on CaMKIIα in tumors and the role of CaMKIIα in the antitumor activity of nano‐C60 have yet to be reported. Here, CAMK2A is linked to neoplasm.